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Age-Dependent Asymmetry of Wrist Position Sense Is Not Influenced by Stochastic Tactile Stimulation

Authors: Anna-Maria Georgarakis, Harshal A. Sonar, Mike D. Rinderknecht, Werner L. Popp, Jaime E. Duarte, Olivier Lambercy, Jamie Paik, Bernard J. Martin, Robert Riener and Verena Klamroth-Marganska

 

Abstract

Stochastic stimulation has been shown to improve movement, balance, the sense of touch, and may also improve position sense. This stimulation can be non-invasive and may be a simple technology to enhance proprioception. In this study, we investigated whether sub-threshold stochastic tactile stimulation of mechanoreceptors reduces age-related errors in wrist position estimation. Fifteen young (24.5 +/- 1.5y) and 23 elderly (71.7 +/- 7.3y) unimpaired, right-handed adults completed a wrist position gauge-matching experiment. In each trial, the participant’s concealed wrist was moved to a target position between 10 and 30 degrees of wrist flexion or extension by a robotic manipulandum. The participant then estimated the wrist’s position on a virtual gauge. During half of the trials, sub-threshold stochastic tactile stimulation was applied to the wrist muscle tendon areas. Stochastic stimulation did not significantly influence wrist position sense. In the elderly group, estimation errors decreased non-significantly when stimulation was applied compared to the trials without stimulation [mean constant error reduction Delta mu(theta conof)=0.8 degrees in flexion and Delta mu(theta conoe)=0.7 degrees in extension direction, p = 0.95]. This effect was less pronounced in the young group [Delta mu(theta cony)=0.2 degrees in flexion and in extension direction, p = 0.99]. These improvements did not yield a relevant effect size (Cohen’s d < 0.1). Estimation errors increased with target angle magnitude in both movement directions. In young participants, estimation errors were non-symmetric, with estimations in flexion [mu(theta conyf)=1.8 degrees, sigma(theta conyf)=7.0 degrees] being significantly more accurate than in extension [mu(theta conye)=8.3 degrees, sigma(theta conye)=9.3 degrees, p < 0.01]. This asymmetry was not present in the elderly group, where estimations in flexion [mu(theta conof)=7.5 degrees, sigma(theta conof)=9.8 degrees] were similar to extension [mu(theta conoe)=7.7 degrees, sigma(theta conoe)=9.3 degrees]. Hence, young and elderly participants performed equally in extension direction, whereas wrist position sense in flexion direction deteriorated with age (p < 0.01). Though unimpaired elderly adults did not benefit from stochastic stimulation, it cannot be deduced that individuals with more severe impairments of their sensory system do not profit from this treatment. While the errors in estimating wrist position are symmetric in flexion and extension in elderly adults, young adults are more accurate when estimating wrist flexion, an effect that has not been described before.

Reference

  • Published in: Frontiers In Human Neuroscience
  • DOI: 10.3389/fnhum.2020.00065
  • Read paper
  • Date: 2020
Posted on: February 23, 2021

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

  • Authors: Formento, Emanuele; Minassian, Karen; Wagner, Fabien; Mignardot, Jean-Baptiste; Le Goff-Mignardot, Camille Georgette Marie; Rowald, Andreas; Bloch, Jocelyne; Micera, Silvestro; Capogrosso, Marco; Courtine, Grégoire

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and proprioceptive information in humans. Computational simulations and preclinical and clinical experiments reveal that EES blocks a significant amount …

Posted on: June 18, 2019

Muscle Spindle Feedback Directs Locomotor Recovery And Circuit Reorganization After Spinal Cord Injury

  • Authors: Takeoka, Aya; Vollenweider, Isabel; Courtine, Gregoire; Arber, Silvia

Reference

Posted on: December 2, 2015