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Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

  • Authors: Formento, Emanuele; Minassian, Karen; Wagner, Fabien; Mignardot, Jean-Baptiste; Le Goff-Mignardot, Camille Georgette Marie; Rowald, Andreas; Bloch, Jocelyne; Micera, Silvestro; Capogrosso, Marco; Courtine, Grégoire

  Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and proprioceptive information in humans. Computational simulations and preclinical and clinical experiments reveal that EES blocks a significant …

Posted on: June 18, 2019

Muscle Spindle Feedback Directs Locomotor Recovery And Circuit Reorganization After Spinal Cord Injury

  • Authors: Takeoka, Aya; Vollenweider, Isabel; Courtine, Gregoire; Arber, Silvia

Reference

Posted on: December 2, 2015