Search
Close
  • About Us
    • Governance
    • Our Team
    • Labs
    • Open positions
    • Alumni
  • Research
    • Wearable robotics
      • ReGait++
      • Third Arm
    • Rescue Robotics
      • Flying Robots
      • Legged robots
      • Collaboration, Learning and Tests
    • Educational robotics
      • Cellulo
      • Thymio
    • Publications
    • Open Science
  • Education
    • How to get into robotics
      • How our professors got into robotics
      • How our researchers got started
    • Robotics for kids
      • Activities for Kids
      • R2t2 Mars Mission
    • Graduate Programs in Robotics
    • Resources
  • Tech Transfer
    • Researchers expertise
    • Spin-Offs
    • Swiss Robotics Day
    • Swiss Robotics Ecosystem
    • Resources
  • Equal Opportunities
    • Robotics for Girls
    • Master students
    • Young Researchers
    • Building Equality
    • Women in Robotics
    • Resources
  • Awards & Programs
    • Spin-Fund
    • Master Students Exchange Program
    • PhD/Postdoc exchange program
    • Award for Career Development
    • Swiss Robotics Masters Award
    • Award for Scientific Visibility
    • Women keynote speakers
    • Best Paper Award
    • Ukrainian researchers
  • Outreach
    • Swiss Drone Days
    • Cybathlon
    • Swiss Robotics Days
    • Other Outreach Events
  • Contact
Menu
  • About Us
    • Governance
    • Our Team
    • Labs
    • Open positions
    • Alumni
  • Research
    • Wearable robotics
      • ReGait++
      • Third Arm
    • Rescue Robotics
      • Flying Robots
      • Legged robots
      • Collaboration, Learning and Tests
    • Educational robotics
      • Cellulo
      • Thymio
    • Publications
    • Open Science
  • Education
    • How to get into robotics
      • How our professors got into robotics
      • How our researchers got started
    • Robotics for kids
      • Activities for Kids
      • R2t2 Mars Mission
    • Graduate Programs in Robotics
    • Resources
  • Tech Transfer
    • Researchers expertise
    • Spin-Offs
    • Swiss Robotics Day
    • Swiss Robotics Ecosystem
    • Resources
  • Equal Opportunities
    • Robotics for Girls
    • Master students
    • Young Researchers
    • Building Equality
    • Women in Robotics
    • Resources
  • Awards & Programs
    • Spin-Fund
    • Master Students Exchange Program
    • PhD/Postdoc exchange program
    • Award for Career Development
    • Swiss Robotics Masters Award
    • Award for Scientific Visibility
    • Women keynote speakers
    • Best Paper Award
    • Ukrainian researchers
  • Outreach
    • Swiss Drone Days
    • Cybathlon
    • Swiss Robotics Days
    • Other Outreach Events
  • Contact
Search
Close
  • NCCR Robotics
    • Highlights
    • Governance
    • Our team
    • Labs
    • Past programs
    • Alumni
    • Open positions in robotics
  • Research
    • Wearable Robotics
      • ReGait++
      • Third Arm
    • Rescue Robotics
      • Flying robots
      • Legged robots
      • Collaborations, learning and tests
    • Educational Robotics
      • Cellulo
      • Thymio
    • Publications
    • Open Science
    • Research resources
  • Education
    • How to get into robotics
      • How our professors got into robotics
      • How our researchers got started
    • Robotics for kids
      • Activities for kids
      • R2t2 Mars mission
    • Graduate programs in robotics
    • Resources
  • Tech Transfer
    • Researchers expertise
    • Spin-Offs
    • Swiss Robotics Day
    • Swiss Robotics Ecosystem
    • Resources
  • Equal Opportunities
    • Building equality
    • Women in Robotics
    • Resources
  • Outreach
    • Swiss Robotics Days
    • Swiss Drone Days
    • Cybathlon
    • Photo exhibit
    • Other Outreach Events
Menu
  • NCCR Robotics
    • Highlights
    • Governance
    • Our team
    • Labs
    • Past programs
    • Alumni
    • Open positions in robotics
  • Research
    • Wearable Robotics
      • ReGait++
      • Third Arm
    • Rescue Robotics
      • Flying robots
      • Legged robots
      • Collaborations, learning and tests
    • Educational Robotics
      • Cellulo
      • Thymio
    • Publications
    • Open Science
    • Research resources
  • Education
    • How to get into robotics
      • How our professors got into robotics
      • How our researchers got started
    • Robotics for kids
      • Activities for kids
      • R2t2 Mars mission
    • Graduate programs in robotics
    • Resources
  • Tech Transfer
    • Researchers expertise
    • Spin-Offs
    • Swiss Robotics Day
    • Swiss Robotics Ecosystem
    • Resources
  • Equal Opportunities
    • Building equality
    • Women in Robotics
    • Resources
  • Outreach
    • Swiss Robotics Days
    • Swiss Drone Days
    • Cybathlon
    • Photo exhibit
    • Other Outreach Events

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Publication date:

  • 27 January 2021

Authors:

Jordan W. Squair
Matthieu Gautier
Lois Mahe
Jan Elaine Soriano
Andreas Rowald
Arnaud Bichat
Newton Cho
Mark A. Anderson
Nicholas D. James
Jerome Gandar
Anthony V. Incognito
Giuseppe Schiavone
Zoe K. Sarafis
Achilleas Laskaratos
Kay Bartholdi
Robin Demesmaeker
Salif Komi
Charlotte Moerman
Bita Vaseghi
Berkeley Scott
Ryan Rosentreter
Claudia Kathe
Jimmy Ravier
Laura McCracken
Xiaoyang Kang
Nicolas Vachicouras
Florian Fallegger
Ileana Jelescu
YunLong Cheng
Qin Li
Rik Buschman
Nicolas Buse
Tim Denison
Sean Dukelow
Rebecca Charbonneau
Ian Rigby
Steven K. Boyd
Philip J. Millar
Eduardo Martin Moraud
Marco Capogrosso
Fabien B. Wagner
Quentin Barraud
Erwan Bezard
Stéphanie P. Lacour
Jocelyne Bloch
Grégoire Courtine
Aaron A. Phillips

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival, impairs neurological recovery, increases the risk of cardiovascular disease, and reduces quality of life. Haemodynamic instability in this context is due to the interruption of supraspinal efferent commands to sympathetic circuits located in the spinal cord, which prevents the natural baroreflex from controlling these circuits to adjust peripheral vascular resistance. Epidural electrical stimulation (EES) of the spinal cord has been shown to compensate for interrupted supraspinal commands to motor circuits below the injury, and restored walking after paralysis. Here, we leveraged these concepts to develop EES protocols that restored haemodynamic stability after SCI. We established a preclinical model that enabled us to dissect the topology and dynamics of the sympathetic circuits, and to understand how EES can engage these circuits. We incorporated these spatial and temporal features into stimulation protocols to conceive a clinical-grade biomimetic haemodynamic regulator that operates in a closed loop. This ‘neuroprosthetic baroreflex’ controlled haemodynamics for extended periods of time in rodents, non-human primates and humans, after both acute and chronic SCI. We will now conduct clinical trials to turn the neuroprosthetic baroreflex into a commonly available therapy for people with SCI.

Reference
Doi: https://doi.org/10.1038/s41586-020-03180-w
Published in: Nature,
 Volume 590,
 Pages 308–314
Read the paper
Version: Published
Access: Open Access
Download
  • Innovation Booster Robotics
  • News
  • Past Events
  • Contact
  • Innovation Booster Robotics
  • News
  • Past Events
  • Contact
  • Journalists and media
  • News bulletin archive
  • Newsletter archive
  • Journalists and media
  • News bulletin archive
  • Newsletter archive
Twitter Linkedin Youtube
NCCR Robotics partner institutions

Leading house

epfl_white

Co-Leading house

eth_white
unizuerich_white
idsia_white
unibe_all_white
empa-all-white
unibasel_white

This website was built by NCCR Robotics and provides useful information on Swiss Robotics. From December 2022, it is no longer updated.

Copyright © 2022 NCCR Robotics. All rights reserved.