Search
Close
  • About Us
    • Governance
    • Our Team
    • Labs
    • Open positions
    • Alumni
  • Research
    • Wearable robotics
      • ReGait++
      • Third Arm
    • Rescue Robotics
      • Flying Robots
      • Legged robots
      • Collaboration, Learning and Tests
    • Educational robotics
      • Cellulo
      • Thymio
    • Publications
    • Open Science
  • Education
    • How to get into robotics
      • How our professors got into robotics
      • How our researchers got started
    • Robotics for kids
      • Activities for Kids
      • R2t2 Mars Mission
    • Graduate Programs in Robotics
    • Resources
  • Tech Transfer
    • Researchers expertise
    • Spin-Offs
    • Swiss Robotics Day
    • Swiss Robotics Ecosystem
    • Resources
  • Equal Opportunities
    • Robotics for Girls
    • Master students
    • Young Researchers
    • Building Equality
    • Women in Robotics
    • Resources
  • Awards & Programs
    • Spin-Fund
    • Master Students Exchange Program
    • PhD/Postdoc exchange program
    • Award for Career Development
    • Swiss Robotics Masters Award
    • Award for Scientific Visibility
    • Women keynote speakers
    • Best Paper Award
    • Ukrainian researchers
  • Outreach
    • Swiss Drone Days
    • Cybathlon
    • Swiss Robotics Days
    • Other Outreach Events
  • Contact
Menu
  • About Us
    • Governance
    • Our Team
    • Labs
    • Open positions
    • Alumni
  • Research
    • Wearable robotics
      • ReGait++
      • Third Arm
    • Rescue Robotics
      • Flying Robots
      • Legged robots
      • Collaboration, Learning and Tests
    • Educational robotics
      • Cellulo
      • Thymio
    • Publications
    • Open Science
  • Education
    • How to get into robotics
      • How our professors got into robotics
      • How our researchers got started
    • Robotics for kids
      • Activities for Kids
      • R2t2 Mars Mission
    • Graduate Programs in Robotics
    • Resources
  • Tech Transfer
    • Researchers expertise
    • Spin-Offs
    • Swiss Robotics Day
    • Swiss Robotics Ecosystem
    • Resources
  • Equal Opportunities
    • Robotics for Girls
    • Master students
    • Young Researchers
    • Building Equality
    • Women in Robotics
    • Resources
  • Awards & Programs
    • Spin-Fund
    • Master Students Exchange Program
    • PhD/Postdoc exchange program
    • Award for Career Development
    • Swiss Robotics Masters Award
    • Award for Scientific Visibility
    • Women keynote speakers
    • Best Paper Award
    • Ukrainian researchers
  • Outreach
    • Swiss Drone Days
    • Cybathlon
    • Swiss Robotics Days
    • Other Outreach Events
  • Contact
Search
Close
  • NCCR Robotics
    • Highlights
    • Governance
    • Our team
    • Labs
    • Past programs
    • Alumni
    • Open positions in robotics
  • Research
    • Wearable Robotics
      • ReGait++
      • Third Arm
    • Rescue Robotics
      • Flying robots
      • Legged robots
      • Collaborations, learning and tests
    • Educational Robotics
      • Cellulo
      • Thymio
    • Publications
    • Open Science
    • Research resources
  • Education
    • How to get into robotics
      • How our professors got into robotics
      • How our researchers got started
    • Robotics for kids
      • Activities for kids
      • R2t2 Mars mission
    • Graduate programs in robotics
    • Resources
  • Tech Transfer
    • Researchers expertise
    • Spin-Offs
    • Swiss Robotics Day
    • Swiss Robotics Ecosystem
    • Resources
  • Equal Opportunities
    • Building equality
    • Women in Robotics
    • Resources
  • Outreach
    • Swiss Robotics Days
    • Swiss Drone Days
    • Cybathlon
    • Photo exhibit
    • Other Outreach Events
Menu
  • NCCR Robotics
    • Highlights
    • Governance
    • Our team
    • Labs
    • Past programs
    • Alumni
    • Open positions in robotics
  • Research
    • Wearable Robotics
      • ReGait++
      • Third Arm
    • Rescue Robotics
      • Flying robots
      • Legged robots
      • Collaborations, learning and tests
    • Educational Robotics
      • Cellulo
      • Thymio
    • Publications
    • Open Science
    • Research resources
  • Education
    • How to get into robotics
      • How our professors got into robotics
      • How our researchers got started
    • Robotics for kids
      • Activities for kids
      • R2t2 Mars mission
    • Graduate programs in robotics
    • Resources
  • Tech Transfer
    • Researchers expertise
    • Spin-Offs
    • Swiss Robotics Day
    • Swiss Robotics Ecosystem
    • Resources
  • Equal Opportunities
    • Building equality
    • Women in Robotics
    • Resources
  • Outreach
    • Swiss Robotics Days
    • Swiss Drone Days
    • Cybathlon
    • Photo exhibit
    • Other Outreach Events

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Publication date:

Authors:

Authors: Asboth, Leonie; Friedli, Lucia; Beauparlant, Janine; Martinez-Gonzalez, Cristina; Anil, Selin; Rey, Elodie; Baud, Laetitia; Pidpruzhnykova, Galyna; Anderson, Mark A.; Shkorbatova, Polina; Batti, Laura; Pagès, Stephane; Kreider, Julie; Schneider, Bernard L.; Barraud, Quentin; Courtine, Grégoire

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished all motor cortex projections below injury. However, the motor cortex immediately regained adaptive control over the paralyzed legs during electrochemical neuromodulation of lumbar circuits. Glutamatergic reticulospinal neurons with residual projections below the injury relayed the cortical command downstream. Gravity-assisted rehabilitation enabled by the neuromodulation therapy reinforced these reticulospinal projections, rerouting cortical information through this pathway. This circuit reorganization mediated a motor cortex–dependent recovery of natural walking and swimming without requiring neuromodulation. Cortico–reticulo–spinal circuit reorganization may also improve recovery in humans.

Reference

  • Published in: Nature Neuroscience (Volume 21)
  • DOI: 10.1038/s41593-018-0093-5
  • Read paper
  • Date: 2018
Reference
Read the paper
  • Innovation Booster Robotics
  • News
  • Past Events
  • Contact
  • Innovation Booster Robotics
  • News
  • Past Events
  • Contact
  • Journalists and media
  • News bulletin archive
  • Newsletter archive
  • Journalists and media
  • News bulletin archive
  • Newsletter archive
Twitter Linkedin Youtube
NCCR Robotics partner institutions

Leading house

epfl_white

Co-Leading house

eth_white
unizuerich_white
idsia_white
unibe_all_white
empa-all-white
unibasel_white

This website was built by NCCR Robotics and provides useful information on Swiss Robotics. From December 2022, it is no longer updated.

Copyright © 2022 NCCR Robotics. All rights reserved.